About the Rose-Burek-Caturegli Laboratory
|Noel R. Rose, M.D., Ph.D.
||C. Lynne Burek, Ph.D.
||Patrizio Caturegli, M.D.|
Our laboratory is dedicated to the study of autoimmune diseases. It includes both a research component and a clinical component.
Our research laboratory focuses on the study of two organ-specific autoimmune diseases: myocarditis and thyroiditis. The people working at the moment in the laboratory, their expertise and research interests are listed below. For fellowship opportunities, please contact
Dr. Rose, or
Dr. Burek, or
Our clinical laboratory specializes in the detection of autoantibodies, using immunofluorescence, hemagglutination or ELISA techniques. At the moment the menu offers 13 autoantibody tests which are performed by Monica Talor.
Markers of autoimmune endocrinopathies
- Thyroglobulin antibodies (hemagglutination)
- Microsomal (TPO) antibodies (hemagglutination)
- Adrenal antibodies (indirect immunofluorescence)
Autoantibodies to the two major thyroid antigens, thyroglobulin and thyroid peroxidase (TPO) are found in autoimmune thyroid conditions. A subset of patients may also develop antibodies to gastric parietal cells or to the adrenal gland. These latter antibodies are also found by themselves in other autoimmune-associated gastritic disorders or in Addison's disease, respectively.
Markers of autoimmune cardiovascular disorders
- Cardiac antibodies (indirect immunofluorescence)
- ANCA (indirect immunofluorescence)
- PR3 (ELISA)
- MPO (ELISA)
Many types of necrotizing vasculitis disorders involving small to medium size vessels have been associated with antibodies to cytoplasmic antigens of neutrophils. Some of the disorders are Wegener's granulomatosis, crescentic necrotizing glomerulonephritis, and microscopic polyangiitis. Two patterns are seen by indirect immunofluorescence: cytoplasmic (c-ANCA) or perinuclear (p-ANCA). The major antigen for c-ANCA is a serine protease 3 (PR3), while the major antigen for p-ANCA is myeloperoxidase (MPO).
Markers of autoimmune gastro-intestinal disorders
- Smooth muscle antibodies (indirect immunofluorescence)
- Mitochondrial antibodies (indirect immunofluorescence)
- IgA endomysial antibodies (indirect immunofluorescence)
- IgA reticulin antibodies (indirect immunofluorescence)
- Tissue transglutaminase (ELISA)
- Gastric parietal cell antibodies (indirect immunofluorescence)
Several autoantibodies are associated with different forms of autoimmune intestinal disorders. Smooth muscle antibodies are found in chronic autoimmune hepatitis , while mitochondrial antibodies are associated with primary biliary cirrhosis . An atypical p-ANCA is seen in inflammatory bowel disease, Crohn's Disease, or chronic sclerosing cholangitis. Celiac disease has a high association with an IgA antibody to endomysium or, less frequently, to reticulin.