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| Vitiligo |
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Definition: Vitiligo is an acquired disorder of the skin caused by the partial or complete loss of melanocytes (the pigment-producing cells located in the basal layer of the epidermis). Description: Vitiligo occurs equally in all sexes and races, but lesions are most noticeable in darkly pigmented individuals. Vitiligo usually presents with a well-demarcated regimented area, which may not be noticed by the patient, usually located on sites of stretch and pressure (such as elbow, knee, dorsum of hands and fingers). From the patient’s perspective, the worst consequences are the psychological and social problems that result. Histological examination of the skin reveals loss of melanocytes, in contrast to albinism, where the melanocytes are present but are not capable of synthesizing melanin. There are several theories about the pathogenesis of vitiligo. Autoimmunity is one of these, although, at the moment, there is only circumstantial evidence that vitiligo is an autoimmune disease. This evidence includes:
Pathogenesis: A recent review on the pathogenesis and treatment of vitiligo can be read by clicking here (Ref 9). |
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Links to other Resources: www.vitiligosociety.org.uk www.nvfi.org |
