|What is Autoimmunity?|
|Definition of Autoimmunity|
|Definition of Autoimmune Disease|
|Broad Spectrum of Autoimmune Disease|
|A Collective Approach|
Broad Spectrum of Autoimmune Disease
Autoimmune diseases are a major threat to the health of all Americans. At least ten million Americans suffer from the more than eighty illnesses caused by autoimmunity. They are a special threat to women; about 75% of the patients are women. Autoimmune diseases are among the ten leading causes of death among women in all age groups up to 65. The bar graph shows the prevalence of the top 10 autoimmune diseases in the United States in 1996 (from Jacobson DL et al. Clin Immunol Immunopathol, 84: 223-243, 1997).
The broad spectrum of autoimmune diseases. Autoimmune diseases can strike any part of the body, and thus symptoms vary widely and diagnosis and treatment are often difficult. The broad spectrum of autoimmune diseases includes multiple sclerosis and the severe type 1 diabetes mellitus. Some autoimmune diseases such as lupus and pemphigus can be life threatening unless properly diagnosed and treated. Chronic autoimmune disorders like rheumatoid arthritis cripple the patient and also create heavy burdens on patients families. Some types of uveitis may cause blindness. Diseases such as scleroderma require skillful, lifelong treatment. Still other autoimmune diseases, including Graves disease and chronic thyroiditis, can be successfully treated if correctly diagnosed, but they are frequently missed because of their subtle onset.
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